If you listen to audiobooks on your iPod you wouldn’t want to get that data submitted to last.fm with the rest of the music mp3 files. iScrobbler 2.0 has a series of hidden configuration options accessible from the terminal, and there’s one to filter the tracks by name or id3, so all you’d have to do is tag your audiobooks with the appropriate genre.
I’m using the following filter and it’s working great for me (copy-paste this line on a terminal to activate it):
defaults write org.bergstrand.iscrobbler "Track Filters" ‘("Speech", "Audiobook", "Audiobooks", "Audio Book", "Vocal")’